PDB ID 1AOI
Research in the Volle Laboratory looks at the interactions between DNA and histone proteins as they form nucleosomes (the most basic unit of DNA packaging in the cell). Specifically, we are interested in regions of the genome that contain short repeating segments of DNA and the changes in nucleosome formation that occur as the number of repeats increase. We are also interested in the effect of specific histone proteins on nucleosome formation and stability.
Monroe D, doi:10.1371/journal.pbio.0050307
In addition to our work in nucleosome formation, we are also investigating the biophysical properties of bacterial biofilms. Biofilms are interconnected communities of bacteria attached to surfaces. By living as a community, they can protect themselves from harsh environmental conditions and antimicrobial agents. In fact, you likely experience a biofilm every morning when you wake up and feel a film on your teeth!